Inkampani ye-biotech, i-Moderna, Inc. imemezele ukuthi i-'mRNA-1273', umuthi wabo wokugomela i-mRNA ngokumelene ne-coronavirus yenoveli ibonise imiphumela emihle ezivivinyweni zomtholampilo zesigaba 1.
Emjahweni wokuthuthukiswa kwemijovo yokwelapha Covid-19, IModerna Inc., yenza isimemezelo ngoMeyi 18, 2020 mayelana nemiphumela emihle yemiphumela yabo umuthi wokugomela i-mRNA ebizwa nge-mRNA-12731. Ucwaningo lweSigaba I luveze ukuthi UMRNA-1273 umuthi wokugoma i-mRNA-1273 ucuphe impendulo yokuzivikela komzimba okuholela ekunciphiseni amazinga e-antibody kubo bonke ababambiqhaza bokuqala abayisishiyagalombili kumaqoqo omthamo we-25 µg no-100 µg. I-antibody titer engathathi hlangothi yafinyelela ezingeni elifanayo njengoba libonwa ezigulini ezaziluleme esifweni se-COVID-19.
umgomo we-mRNA-1273 ngokuvamile yayiphephile futhi ibekezelelwa kahle. Iphrofayili yokuphepha ibihambisana naleyo ebonwe ezifundweni zangaphambilini zomtholampilo zeModerna ezenziwe ngemijovo yokugomela izifo ezithathelwanayo.
Ucwaningo lwangaphambi komtholampilo kumagundane agonywe ngawo i-mRNA-1273, ngemuva kokuphonswa inselelo ne-SARS-CoV-2 igciwane wabonisa lokho i-mRNA-1273 ivimbele ukuphindaphindeka kwegciwane futhi kwaholela ekukhiqizweni kwama-antibodies ane-titre efana naleyo ekhiqizwa ezigulini ezibambe iqhaza ocwaningweni lweSigaba I.
Imiphumela ekhuthazayo etholwe ocwaningweni lweSigaba 1 izosiza ukuqalisa izivivinyo ezisele maduze, kanti iSigaba sesi-3 kulindeleke ukuthi siqale ngoJulayi 2020, kusalindwe ukuphothulwa kwesivumelwano somtholampilo futhi uma konke kuhamba kahle, umgomo uzobona ukukhanya kosuku, usulungele zinikezwe iziguli ngokushesha kunalokho obekulindelwe, njengoba i-FDA inikeze igama le-Fast Track2 kuphrojekthi.
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Imithombo:
1. I-Moderna, Inc. 2020. Ukukhishwa kwabezindaba - I-Moderna Imemezela Idatha Enhle Yesigaba Sokuqala seSigaba 1 sayo i-mRNA Umuthi wokugoma (i-mRNA-1273) ngokumelene Inoveli Coronavirus. Kuthunyelwe ngomhla ka-18 Meyi 2020. Itholakala ku-inthanethi ku- https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine
2. I-Moderna, Inc. 2020. Ukukhishwa kwabezindaba - I-Moderna Ithola I-FDA Esheshayo Ukuqokwa Komuthi Wokugoma we-mRNA (mRNA-1273) Wokulwa Ne-Novel Coronavirus. Kuthunyelwe ngomhla ka-12 Meyi 2020. Itholakala ku-inthanethi ku- https://investors.modernatx.com/news-releases/news-release-details/moderna-receives-fda-fast-track-designation-mrna-vaccine-mrna
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