NgoJuni 2020, isilingo se-RECOVERY esivela eqenjini labacwaningi base-Oxford University UK sabika ukusetshenziswa kwe-dexamethasone ebiza kancane.1 yokwelashwa kweziguli ezigula kakhulu ze-COVID-19 ngokunciphisa ukuvuvukala. Muva nje, umuthi osuselwa kumaprotheni, obizwa nge-Aviptadil, ulandelelwe ngokushesha yi-FDA ngokwenza izivivinyo zomtholampilo ngokumaphakathi kakhulu iziguli ze-COVID. Icala laqala ngo-1st NgoJulayi 2020 kanye nemiphumela yokuqala ikhuthaza kakhulu.
Umjaho uphezu kokwenza imithi ephephile futhi esebenzayo yokwelapha Covid-19, esibambezele umhlaba wonke futhi yabangela izinselele ezibalulekile ezihlobene nezomnotho nempilo emazweni angaphezu kuka-200 emhlabeni jikelele. Nakuba imishanguzo embalwa ye-molecule encane elwa namagciwane ivunyelwe njengesinyathelo sokulungisa, kunemiphumela emibi ehlobene yale mithi ye-molecule encane. Ukuzingela kuvuliwe ngemithi ethile esekelwe kumaprotheni ehlanganisa amasosha omzimba e-monoclonal2 eziqondile futhi ezinemiphumela emibi emincane. Ngaphezu kwalokho, ngokombono wesikhathi eside wokuvikela inani labantu bomhlaba, umhlaba wonke ulindele ngabomvu umuthi wokugoma ophephile nosebenzayo ozosiza ukuthuthukisa ukungatheleleki okusebenzayo ngokumelene naleli gciwane futhi ubuyisele impilo kwesijwayelekile njengoba kwakunjalo ngaphambi kwe-COVID-19.
I-Aviptadil iwukwakhiwa kwe-synthetic Vasoactive Intestinal Polypeptide (VIP). I-VIP yaqala ukutholwa ngo-1970 nguDkt Sami Said, uchwepheshe wezokwelapha zamaphaphu. Ikhona ekugxilweni okuphezulu emaphashini lapho ibandakanyeka ekuphumuleni kwemigudu yomoya kanye nemikhumbi yamaphaphu. I-VIP ikhonjwe njengesici esinamandla sokulwa nokuvuvukala, esisebenza ngokulawula ukukhiqizwa kwabo bobabili abaxhumanisi abamelene nokuvuvukala.3 kanye nemisebenzi ngokuvimbela ama-cytokines avuthayo.
Ukusetshenziswa kwe-Aviptadil ezivivinyweni zomtholampilo ezisanda kuvunywa kuholele ekululameni kweziguli ekuhlulekeni kokuphefumula ezigulini ezigula kakhulu ze-Covid-19. Lapho benikeza umuthi, kususe ukuvuvukala kwamaphaphu abo, kwathuthukisa amazinga abo komoyampilo wegazi futhi kwanciphisa izimpawu zokuvuvukala ngamaphesenti angaphezu kwama-50 ezigulini ezingaphezu kwe-15.4. Kodwa-ke, idatha eyengeziwe evela esivivinyweni somtholampilo iyadingeka ukuze kusungulwe ukuphepha nokusebenza kwe-Aviptadil ngenani elikhulu leziguli kuhlanganise neziguli ezinobunzima obuncane bokugula ukuze kuqinisekiswe ukuthi ukubhekwa okufanayo kubonakala.
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References:
- Soni, R, 2020. I-Dexamethasone: Ingabe Ososayensi Balitholile Ukwelapha Iziguli Ezigula Kakhulu I-COVID-19? Isayensi yaseYurophu. Ishicilelwe ngo-Agasti 14, 2020. Itholakala ku-inthanethi kokuthi http://scientificeuropean.co.uk/dexamethasone-have-scientists-found-cure-for-severely-ill-covid-19-patients/
- Soni, R, 2020. Ama-Monoclonal Antibodies kanye Nezidakamizwa Ezisekelwe Kumaprotheni Angase Asetshenziselwe Ukwelapha Iziguli Ze-COVID-19. Isayensi yaseYurophu. Ishicilelwe ngo-Agasti 14, 2020. Itholakala ku-inthanethi kokuthi http://scientificeuropean.co.uk/monoclonal-antibodies-and-protein-based-drugs-could-be-used-to-treat-covid-19-patients/
- I-Delgado M, i-Abad C, i-Martinez C, i-Juarranz MG, i-Arranz A, i-Gomariz RP, i-Leceta J. I-peptide yamathumbu e-Vasoactive e-immune system: indima yokwelapha engaba khona ezifweni ezivuthayo kanye ne-autoimmune. J Mol Med (2002) 80:16–24. I-DOI: https://doi.org/10.1007/s00109-001-0291-5
- Youssef JG, Zahiruddin F, Al-Saadi M, Yau S, Goodarzi A, Huang HJ, Javitt JC. Umbiko Omfishane: Ukululama Ngokushesha Komtholampilo Ku-Critical COVID-19 Ngokuhluleka Kokuphefumula Esigulini Sokufakelwa Kwamaphaphu Esilashwe Nge-Intravenous Vasoactive Intestinal Peptide. I-Preprints 2020, 2020070178 DOI: https://doi.org/10.20944/preprints202007.0178.v2
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