I-BNT116 kanye ne-LungVax abantu abazogomela umdlavuza wamaphaphu we-nucleic acid - eyokuqala isuselwe kubuchwepheshe be-mRNA obufana “nemithi yokugomela i-COVID-19 mRNA” efana ne-BNT162b2 ye-Pfizer/BioNTech kanye ne-Moderna's mRNA-1273 kuyilapho umgomo we-LungVax ufana ne-Oxford/AstraZe -19 umgomo. Ubuchwepheshe obufanayo buyasetshenziswa ukuthuthukisa i-immunotherapy kanye nemigomo yokuvimbela umdlavuza wamaphaphu. Manje, isiguli somdlavuza wamaphaphu sithole umuthi wokugoma wokuqala we-BNT116 mRNA esivivinyweni somtholampilo sokutadisha i-immunotherapy yomdlavuza wamaphaphu ongewona omncane (NSCLC) esibhedlela i-UCL eLondon.
Isiguli somdlavuza wamaphaphu e-UK sithole umgomo wophenyo we-mRNA womdlavuza wamaphaphu ongewona omncane (NSCLC) ohlolweni lomtholampilo.
Umuntu ozogoma waziwa ngokuthi I-BNT116 futhi ikhiqizwa yi-BioNTech, inkampani yaseJalimane ye-biotech. Isekelwe kubuchwepheshe be-mRNA obasetshenziswa ngesikhathi sodlame ukukhiqiza “imithi yokugomela i-COVID-19 mRNA” efana ne-BNT162b2 ye-Pfizer/BioNTech kanye ne-Moderna's mRNA-1273.
Umuthi wokugoma ophenywayo i-BNT116, njengeminye imigomo nemithi yokwelapha esekelwe ku-mRNA, usebenzisa i-RNA yesigijimi esinekhodi eveza ama-antigen (ama-tumor marker avamile kuleli cala) emzimbeni abangela ukusabela kwamasosha omzimba futhi alwe namaseli omdlavuza. Kulokhu, umuntu ozogomela i-BNT116 uhlinzeka nge-immunotherapy esigulini. Ngokungafani nokwelashwa ngamakhemikhali, okuqondise kokubili amangqamuzana anomdlavuza nanempilo, ukusabela komzimba ngalo mgomo wophenyo kuqondiswe kumaseli anomdlavuza kuphela.
Uhlolo luhlose ukubhalisa iziguli ezigabeni ezihlukene zomdlavuza wamaphaphu ongewona omncane we-NSCLC ukuze zifunde ukuthi i-BNT116 iphephile futhi ibekezelelwa kahle yini lapho iphathwa njenge-monotherapy noma ihlanganiswe nezinye izindlela zokwelapha ezisunguliwe ukuze kukale noma yimuphi umphumela we-synergistic.
Omunye umuthi wokugoma osuselwa ku-nucleic acid owakhiwa e-UK Umuthi wokugomela i-LungVax, noma ngaphezulu, Umuthi wokugomela i-ChAdOx2-lungvax-NYESO. Lokhu okweziguli ezisengozini yomdlavuza wamaphaphu omusha noma ovelayo ongewona omncane (NSCLC). Lokhu kuqukethe uchungechunge lwekhodi ye-DNA yomaka cell cell futhi isebenza ngomgomo ofanayo nowomgomo we-Oxford/AstraZeneca COVID-19. I-ChAdOx2 (Chimpanzee Adenovirus Oxford 1) isebenzisa i-adenovirus eyenziwe ngofuzo njenge-vector ukuze ithwale isakhi sofuzo sezimpawu zamangqamuzana omdlavuza (MAGE-A3 kanye ne-NYESO) ezivezwa kumangqamuzana omuntu asebenza njengama-antigens ekuthuthukiseni amasosha omzimba asebenzayo ngokumelene nomdlavuza.
Ukuhlolwa komtholampilo komuthi wokugomela i-LungVax (ChAdOx2-lungvax-NYESO) kuzohlola ukuthi ingabe ukuphatha kwawo kungcono yini kuvimbela umdlavuza wengqamuzana wamaphaphu ongewona omncane (NSCLC) kunokuthi “ukungagomi”.
Amaseli omdlavuza wamaphaphu ahlukile kumaseli wamaphaphu avamile ngokuba nama-neoantigens endaweni yawo yamaseli akha izinguquko ezidala umdlavuza ngenxa ye-DNA yeseli. Imishanguzo yokugomela i-BNT116 kanye ne-LungVax iveza ama-neoantigens asemzimbeni aqala amasosha omzimba ukubona ama-neoantigens njengokungewona. ukuzithiba ngaleyo ndlela kubangele ukuphendula kwamasosha omzimba ukuze kuncishiswe amangqamuzana omdlavuza wamaphaphu.
Cishe abantu abayizigidi eziyi-1.6 babulawa umdlavuza wamaphaphu minyaka yonke. Kuyimbangela enkulu ekufeni kwabantu okuhlobene nomdlavuza emhlabeni wonke. Umdlavuza wamaphaphu ongewona omncane (NSCLC) wenza ama-85% awo wonke amacala omdlavuza wamaphaphu. Ukuhlinzwa, i-chemotherapy kanye ne-radiotherapy kunamandla alinganiselwe ekuthuthukiseni amazinga okusinda yingakho kunesidingo sezindlela ezintsha zokwelapha kanye nokuvimbela umdlavuza wamaphaphu. Muva nje, ubuchwepheshe be-mRNA kanye nemithi yokugoma esekwe ku-DNA ikhombise ukubaluleka kwayo ekubhekaneni nobhubhane lwe-COVID-19. Ubuchwepheshe obufanayo buyasetshenziswa ukuthuthukisa i-immunotherapy kanye nemigomo yokuvimbela umdlavuza wamaphaphu. Amathemba aphezulu anamathiselwe ezivivinyweni zomtholampilo ze-BNT116 kanye ne-LungVax yokugomela umdlavuza wamaphaphu.
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References:
- Izindaba ze-UCLH - Isiguli sokuqala sase-UK sithola umuthi wokugomela umdlavuza wamaphaphu. Ishicilelwe ngomhla ka-23 Agasti 2024. Itholakala e- https://www.uclh.nhs.uk/news/first-uk-patient-receives-innovative-lung-cancer-vaccine
- Izindaba zaseNyuvesi yase-Oxford - Uxhaso olusha lwezimali lokuthuthukisa umuthi wokugomela umdlavuza wamaphaphu wokuqala emhlabeni. Kushicilelwe 22 March 2024. Itholakala e- https://www.ox.ac.uk/news/2024-03-22-new-funding-development-worlds-first-lung-cancer-vaccine & https://www.ndm.ox.ac.uk/news/developing-the-worlds-first-lung-cancer-vaccine
- Inyuvesi yase-Oxford. I-LungVax. Itholakala ngo https://www.oncology.ox.ac.uk/clinical-trials/oncology-clinical-trials-office-octo/prospective-trials/lungvax & https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/phase-iiia-trial-of-chadox1-mva-vaccines-against-mage-a3-ny-eso-1/
- Wang, X., Niu, Y. & Bian, F. Inqubekelaphambili yokuhlolwa kwemithi yokugomela isimila kumdlavuza wamaphaphu weseli ongewona omncane. I-Clin Transl Oncol (2024). Kushicilelwe 23 Agasti 2024. DOI:https://doi.org/10.1007/s12094-024-03678-z
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Izihloko ezihlobene
- I-HIV/AIDS: Umgomo we-mRNA Ubonisa Isithembiso Esivivinyweni Sangaphambi Komtholampilo (2 Mashi 2022)
- Ubuchwepheshe be-RNA: ukusuka eMithini yokuGomela i-COVID-19 kuya ekwelashweni kwesifo i-Charcot-Marie-Tooth (4 February 2022)
- Umuthi wokugoma we-COVID-19 mRNA: Ingqophamlando Kwezesayensi kanye Noshintsho Lwegeyimu Kwezokwelapha (29 Disemba 2020)
- I-mRNA-1273: Umuthi Wokugomela I-mRNA we-Moderna Inc. (I-19 Meyi 2020)
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