I-Neffy (i-epinephrine nasal spray) ivunyelwe yi- FDA yokwelashwa okuphuthumayo kohlobo lwe-I yokungezwani nomzimba okuhlanganisa ne-anaphylaxis esongela ukuphila. Lokhu kunikeza enye indlela yokuphatha i-epinephrine kulabo (ikakhulukazi izingane) abangathandi imijovo futhi babhekene nesimo esisongela ukuphila se-anaphylaxis.
I-epinephrine ukuphela kwendlela yokwelapha esindisa impilo ye-anaphylaxis. Itholakala kuze kube manje kuphela njengoba umjovo uvame ukufakwa ngomzila we-intramuscular (IM) noma we-intravenous (IV). I-Neffy ingumkhiqizo wokuqala we-epinephrine wokwelapha i-anaphylaxis engalawulwa ngomjovo.
Ukugunyazwa kwesifutho samakhala kusekelwe emiphumeleni yocwaningo. Imizila emibili okungukuthi. Isifutho samakhala kanye nomjovo kubonise ukugxila kwegazi kwe-epinephrine okuqhathaniswayo ngemva kokuphathwa. Baphinde babonisa ukunyuka okufanayo komfutho wegazi kanye nesilinganiso senhliziyo okuyimiphumela emibili ebalulekile ye-epinephrine ekwelapheni i-anaphylaxis.
I-Neffy isifutho sekhala esisodwa somthamo owodwa esifakwa ekhaleni elilodwa. Umthamo wesibili (kusetshenziswa isifutho sekhala esisha ekhaleni elifanayo) ungase unikezwe uma kungekho ngcono izimpawu noma izimpawu ziba zimbi kakhulu. Iziguli kungase kudingeke ukuthi zifune usizo lwezokwelapha oluphuthumayo ukuze ziqashwe eduze.
Ukuphikisana yizimo ezithile zamakhala, njengama-polyp wamakhala noma umlando wokuhlinzwa emakhaleni ongathinta ukumuncwa, izimo ezithile ezihlala isikhathi eside kanye nokungezwani komzimba okuhambisana ne-sulfite. Iziguli ezinalezi zimo kufanele zithintane nochwepheshe bezempilo ukuze bacabangele ukusebenzisa umkhiqizo we-epinephrine ojovwayo. Imiphumela emibi evamile ihlanganisa ukucasuka komphimbo, ikhala elilumayo (intranasal paresthesia), ikhanda elibuhlungu, ukungakhululeki emakhaleni, ukuzwa i-jittery, ukuzwa ukuncenceza (paresthesia), ukukhathala, ukuthuthumela, ikhala eligijima (rhinorrhea), ukulunywa ngaphakathi kwekhala (ukulunywa kwamakhala), ukuthimula, isisu. ubuhlungu, izinsini (gingival) ubuhlungu, ukuba ndikindiki emlonyeni (hypoesthesia oral), ukuminyana emakhaleni, isiyezi, isicanucanu nokuhlanza.
Ukungezwani komzimba ukusabela ukusabela okungavamile kwamasosha omzimba womuntu entweni ngokuvamile engabangeli zimpawu
I-Anaphylaxis ibhekwa njengesimo esiphuthumayo sezokwelapha. Kuwukungezwani komzimba okunzima, okusongela ukuphila okuvamise ukubandakanya izingxenye eziningi zomzimba. Ukudla okuthile, imithi kanye nokulunywa yizinambuzane kuyizinto ezivamile zokungezwani komzimba ezingadala i-anaphylaxis. Izimpawu zivame ukwenzeka emaminithini wokuchayeka futhi zihlanganisa, kodwa azikhawulelwe, ukuqubuka, ukuvuvukala, ukulunywa, ukuhlanza, ukuphefumula kanzima kanye nokulahlekelwa ukwazi.
I-FDA inikeze imvume ye-Neffy kwa-ARS Pharmaceuticals.
***
References:
- I-FDA Igunyaza Isifutho Sokuqala Samakhala Sokwelapha I-Anaphylaxis. Kuthunyelwe ngomhla ka-09 Agasti 2024. Itholakala e- https://www.fda.gov/news-events/press-announcements/fda-approves-first-nasal-spray-treatment-anaphylaxis
***
