Imithi elwa namagciwane yamanje esetshenziswa emtholampilo, ngaphezu kokunciphisa amagciwane okuhlosiwe nawo alimaza amagciwane anempilo emathunjini. Ukuphazamiseka kwe-gut microbiome kunemiphumela enobuthi esibindini, ezinso nakwezinye izitho zomzimba. Lolu wudaba okumele ludingidwe. Abacwaningi bathole i-lolamicin, ikhandidethi yemithi elwa namagciwane okutholwe ukuthi iyasebenza ekulweni nezifo ze-gram-negative ngaphandle kokuthinta i-gut microbiome enempilo ezifundweni zangaphambi komtholampilo. Lokhu kuwubufakazi bomqondo wokuthi ama-antibiotic abulala amagciwane e-pathogenic kuyilapho esindisa amagciwane anenzuzo emathunjini angathuthukiswa izifo zegram-negative. Inikeza ithemba lokubhekana nezinkinga ezihlobene nokukhomba ngokungakhethi amagciwane e-gram-negative. Kodwa-ke, iminyaka yocwaningo olwengeziwe iyadingeka ngaphambi kokuba ifinyelele esigabeni sokusetshenziswa emtholampilo.
Iningi kwemithi elwa namagciwane khomba kuphela amagciwane egram-positive noma uqondise womabili amagciwane egram-positive kanye negram-negative. Abanye kwemithi elwa namagciwane ethize kubhaktheriya e-gram-negative (amabhaktheriya ane-gram-negative anengqimba ephindwe kabili yesivikelo odongeni lwamangqamuzana awo okwenza kube nzima ukuwabulala) aphinde abulale amagciwane ane-gram-negative emathunjini. Iziphazamiso ku-gut microbiome zidalwe kanjalo zitholakala zinemiphumela enobuthi/emibi ikakhulukazi esibindini nasezinso. Ngakho-ke isidingo sokwenza ama-antibiotics angabulala ngokukhetha amagciwane e-pathogenic kuyilapho esindisa lawo anenzuzo. Njengoba kubikiwe ephepheni lokucwaninga lakamuva, ososayensi benze isibulala-magciwane esisodwa esibizwa ngokuthi i-lolamicin esitholakale siqondisa ngokukhethekile amagciwane e-gram-negative pathogenic kuyilapho esindisa azuzisayo.
I-Lolamicin iyi-inhibitor ye-Lol (localization of lipoproteins) indlela, uhlelo lwe-lipoprotein-transport olutholakala kuphela kumagciwane e-gram-negative ahluke ngofuzo kubhaktheriya e-pathogenic futhi enenzuzo.
Esikweni lamaseli, lalingenawo umthelela oncomekayo kumabhaktheriya e-gram-positive. Ngemithamo ephezulu, yehlisa kuze kufike ku-90% we-E. coli engazweli emithini eminingi, K. pneumoniae kanye ne-E. cloacae Clinical isolates.
Ukuphathwa ngomlomo kwe-lolamicin kumagundane ane-septicemia engazweli emthini noma inyumoniya kusindise u-100% wamagundane ane-septicemia kanye no-70% wamagundane anenyumoniya. Ngaphezu kwalokho, ukuphathwa kwe-lolamicin akuzange kuholele kunoma yiluphi ushintsho olukhulu ekubunjweni kwe-taxonomic yamagciwane ku-gut microbiome yamagundane phakathi nokwelashwa kwezinsuku ezintathu noma ukululama okulandelayo kwezinsuku ezingama-28.
Le miphumela yocwaningo lwezilwane lwangaphambi komtholampilo iyakhuthaza futhi inikeza ithemba lokubhekana nezinkinga ezihlobene nokukhomba ngokungakhethi amagciwane angenayo igram. Kuwubufakazi bomqondo wokuthi kungenzeka ukuthuthukisa kwemithi elwa namagciwane aqondisa ngokukhethekile amagciwane ayingozi e-gram-negative kuyilapho evikela i-gut microbiome kunoma yimuphi umphumela omubi. Nokho, iminyaka yocwaningo olwengeziwe iyadingeka ukuze kunwetshwe okutholakele.
***
References:
- Muñoz, KA, Ulrich, RJ, Vasan, AK et al. I-antibiotic ye-Gram-negative-selective evikela i-gut microbiome. Imvelo 630, 429–436 (2024). Kushicilelwe: 29 May 2024. DOI: https://doi.org/10.1038/s41586-024-07502-0
- University of Illinois Urbana-Champaign 2024. Izindaba zocwaningo - Imithi elwa namagciwane entsha ibulala amagciwane e-pathogenic, ivikela amagciwane amathumbu anempilo. Kuthunyelwe ngomhla ka-29 Meyi 2024. Itholakala e- https://news.illinois.edu/view/6367/668002791
***
