Ukumelana nama-antibiotic ikakhulukazi amagciwane e-Gram-negative acishe adala inkinga efana nesimo. Imithi elwa namagciwane inoveli iZosurabalpin (RG6006) ibonisa izithembiso. Kutholwe ukuthi kusebenza ngempumelelo ngokumelene nebhaktheriya elingazweli emuthini, i-Gram-negative CRAB ezifundweni zangaphambi komtholampilo.
Ukumelana ne-Antimicrobial (AMR), eqhutshwa ikakhulukazi ukusetshenziswa kabi nokusetshenziswa ngokweqile kwama-antimicrobial, ingenye yezingozi eziphezulu zezempilo zomphakathi.
Ukutheleleka nge-Gram-negative bacteria kuthinta kakhulu. Akulula kwabaningi kwemithi elwa namagciwane ukuwela kokubili ulwelwesi lwangaphakathi nangaphandle olukhona kulesi sigaba samabhaktheriya ukuze angene kumaseli ebhaktheriya ukuze abonise izenzo zokubulala amagciwane. Futhi, amagciwane angenayo i-Gram-negative anqwabelene ngezinga eliphakeme ngokungenakulinganiswa i-antibiotic Ukumelana.
Acinetobacter baumannii igciwane le-Gram-negative. Ukutheleleka ngolunye lwezinhlobo zalo ezibizwa nge-'carbapenem-resistant Acinetobacter baumannii' (CRAB) kunzima ukukwelapha usebenzisa okutholakalayo kwemithi elwa namagciwane. Kunesidingo esiphuthumayo sokwenza ngempumelelo i-antibiotic ngokumelene ne-CARB njengoba izinga lokufa liphezulu (cishe ama-40% -60%) okudalwe kakhulu ukuntuleka kokusebenza okusebenzayo. i-antibiotic. Inqubekelaphambili ebheke kulo mgomo ibikiwe.
Ososayensi bahlonze isigaba samanoveli kwemithi elwa namagciwane okungukuthi, i-tethered macrocyclic peptides (MCPs) esebenza ngokumelene ne-Gram –ve bacteria A. baumannii kuhlanganise ne-CARB ngokuvimba ukuthuthwa kwe-lipopolysaccharide yebhaktheriya isuka kulwelwesi lwangaphakathi iye kulwelwesi olungaphandle.
I-Zosurabalpin (RG6006) kuyinto i-antibiotic ikhandidethi eliyingxenye yekilasi le-'tethered macrocyclic peptides (MCPs)'. Ngaphambili-emtholampilo Izivivinyo ezibandakanya izifundo ze-in vitro kanye nezifundo ze-vivo kumamodeli ezilwane, i-Zosurabalpin itholwe iphumelela ngokumelene nezihlukanisi ezimelana nezidakamizwa ze-'carbapenem-resistant Acinetobacter baumannii' (CRAB) evela ezifundeni ezahlukene. Yanqoba ngempumelelo i-antibiotic-ukumelana nendlela ye-CARB ephakamisa Zosurabalpin inamandla.
Ngakho-ke, umuntu emtholampilo izivivinyo seziqalisiwe ukubheka ukuphepha nokusebenza ngempumelelo Zosurabalpin ekwelapheni izifo ezihlaselayo ezibangelwa yi-CRAB.
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References:
- Zampaloni, C., Mattei, P., Bleicher, K. et al. Inoveli i-antibiotic isigaba esiqondise isithuthi se-lipopolysaccharide. Imvelo (2024). https://doi.org/10.1038/s41586-023-06873-0
- Hawser S., et al 2023. Umsebenzi weNovel Antibiotic Zosurabalpin (RG6006) ngokumelene Imitholampilo I-Acinetobacter Isolates evela e-China, Open Forum Infectious Diseases, Volume 10, Issue Supplement_2, Disemba 2023, ofad500.1754, https://doi.org/10.1093/ofid/ofad500.1754
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