Isikhangiso

2024 Nobel in Chemistry for "Designing protein" kanye "Ne-Predicting protein structure"  

Ingxenye eyodwa Umklomelo KaNobel kuChemistry 2024 uklonyeliswe UDavid Baker "yokuklama amaprotheni wekhompyutha". Enye ingxenye iklonyeliswe ngokuhlanganyela UDemis Hassabis noJohn M. Jumper "ngokubikezela isakhiwo samaprotheni".  

The Umklomelo KaNobel kuKhemistry I-2024 ibona iminikelo emandleni ethu okubikezela ukwakheka kwamaprotheni nokuklama amaprotheni amasha.  

Uhhafu womklomelo uklonyeliswe u-David Baker “ngokwakhiwa kwamaprotheni okuhlanganisa”. Ngo-2003, wakha izinhlobo ezintsha ngokuphelele zamaprotheni esebenzisa ama-amino acid angama-20 ahlukene. Amaprotheni amasha ayengafani nanoma yimaphi amanye amaprotheni futhi asebenza njengemithi, imigomo, ama-nanomaterials nezinzwa ezincane. 

Enye ingxenye inikezwe ngokuhlanganyela uDemis Hassabis noJohn M. Jumper "ngokubikezela kwesakhiwo samaprotheni". Ngo-2020, bathuthukisa ngempumelelo imodeli ye-AI ebizwa I-AlphaFold2 yokubikezela izakhiwo eziyinkimbinkimbi ezinezinhlangothi ezintathu zamaprotheni ezivela ekulandeleni kwe-atheir mino acid. Imodeli yabo ye-AI ibikezela ukwakheka kwawo wonke amaprotheni ayizigidi ezingama-200 akhonjwe kuze kube manje. Leli khono liwusizo ekuqondeni kangcono ukumelana nama-antibiotic nasekwakheni izithombe zama-enzyme angabola ipulasitiki.  

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Imithombo:  

  1. NobelPrize.org. Ukukhishwa kwabezindaba - The Nobel Prize in Chemistry 2024. Kuthunyelwe ngo-9 October 2024. Itholakala e- https://www.nobelprize.org/prizes/chemistry/2024/press-release/  

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