Ingxenye eyodwa Umklomelo KaNobel kuChemistry 2024 uklonyeliswe UDavid Baker "yokuklama amaprotheni wekhompyutha". Enye ingxenye iklonyeliswe ngokuhlanganyela UDemis Hassabis noJohn M. Jumper "ngokubikezela isakhiwo samaprotheni".
The Umklomelo KaNobel kuKhemistry I-2024 ibona iminikelo emandleni ethu okubikezela ukwakheka kwamaprotheni nokuklama amaprotheni amasha.
Uhhafu womklomelo uklonyeliswe u-David Baker “ngokwakhiwa kwamaprotheni okuhlanganisa”. Ngo-2003, wakha izinhlobo ezintsha ngokuphelele zamaprotheni esebenzisa ama-amino acid angama-20 ahlukene. Amaprotheni amasha ayengafani nanoma yimaphi amanye amaprotheni futhi asebenza njengemithi, imigomo, ama-nanomaterials nezinzwa ezincane.
Enye ingxenye inikezwe ngokuhlanganyela uDemis Hassabis noJohn M. Jumper "ngokubikezela kwesakhiwo samaprotheni". Ngo-2020, bathuthukisa ngempumelelo imodeli ye-AI ebizwa I-AlphaFold2 yokubikezela izakhiwo eziyinkimbinkimbi ezinezinhlangothi ezintathu zamaprotheni ezivela ekulandeleni kwe-atheir mino acid. Imodeli yabo ye-AI ibikezela ukwakheka kwawo wonke amaprotheni ayizigidi ezingama-200 akhonjwe kuze kube manje. Leli khono liwusizo ekuqondeni kangcono ukumelana nama-antibiotic nasekwakheni izithombe zama-enzyme angabola ipulasitiki.
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Imithombo:
- NobelPrize.org. Ukukhishwa kwabezindaba - The Nobel Prize in Chemistry 2024. Kuthunyelwe ngo-9 October 2024. Itholakala e- https://www.nobelprize.org/prizes/chemistry/2024/press-release/
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