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I-COVID-19: Okuhlukile kwe-JN.1 kukwazi ukusuleleka okuphezulu kanye nekhono lokuphunyuka lokuzivikela komzimba 

Ukuguqulwa kwe-Spike (S: L455S) kuwuphawu lokuguqulwa kwe-JN.1 okuhlukile okuthuthukisa ngokuphawulekayo amandla ako okugwema amasosha omzimba okuyenza ikwazi ukubalekela ngempumelelo amasosha omzimba Ekilasi 1. Ucwaningo lusekela ukusetshenziswa kwemithi yokugomela ebuyekeziwe ye-COVID-19 enamaprotheni e-spike ukuze kuthuthukiswe umphakathi.  

Ukungena Covid-19 kuye kwabikwa amacala ezingxenyeni eziningi zomhlaba. Okusha i-sub-variant JN.1 (BA.2.86.1.1) eguquke ngokushesha isuka ku-BA.2.86 ehlukile muva nje ibibangela ukukhathazeka.  

I-JN.1 (BA.2.86.1.1) i-sub-variant inokushintshwa kwe-spike okwengeziwe (S: L455S) uma kuqhathaniswa nesandulela sayo i-BA.2.86. Lokhu ukuguquguquka okuphawulekayo kwe-JN.1 okuthuthukisa ngokuphawulekayo amandla ayo okugwema amasosha omzimba okuyenza ikwazi ukubalekela ngempumelelo amasosha omzimba e-Class 1. I-JN.1 iphinde ibe nezinguquko ezintathu kumaprotheni angewona ama-S. Sekukonke, i-JN.1 ikhulise ukusuleleka kanye nekhono lokuphunyuka lokuzivikela komzimba1,2.  

Imithi yokugomela i-COVID-19 isihambe ibanga elide kusukela ubhubhane futhi ibuyekeziwe kubhekiselwa kuphrotheni ye-spike ukuze ihlangabezane nezinselelo ezilethwa izinhlobo ezintsha ezisanda kuvela.  

Ucwaningo lwakamuva luphakamisa ukuthi i-monovalent ebuyekeziwe umuthi wokugomela i-mRNA (I-XBB.1.5 MV) iyasebenza ekwandiseni amasosha omzimba e-serum virus-neutralization ngokuphawulekayo ngokumelene nokuhlukahluka okuncane okuningi okuhlanganisa ngokumelene ne-JN.1. Lolu cwaningo lusekela ukusetshenziswa kwemithi yokugomela ebuyekeziwe ye-COVID-19 enamaprotheni e-spike ukuze kuthuthukiswe umphakathi3.  

Uma ngabe okuhlukile kwe-JN.1 kuveza ubungozi obukhulayo kumpilo yomphakathi ngokuhlobene nokunye okuhlukile okusatshalaliswayo njengamanje, i-CDC ithi abukho ubufakazi4.  

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References:  

  1. Yang S., et al 2023. Ukuvela okusheshayo kwe-SARS-CoV-2 BA.2.86 kuya ku-JN.1 ngaphansi kwengcindezi enkulu yokuzivikela komzimba. Ukuphrinta kuqala i-bioRxiv. Kuthunyelwe ngoNovemba 17, 2023. DOI: https://doi.org/10.1101/2023.11.13.566860  
  2. Kaku Y., et al 2023. Izici ze-Virological zokuhluka kwe-SARS-CoV-2 JN.1. Ukuphrinta kuqala i-bioRxiv. Kuthunyelwe Disemba 09, 2023. DOI: https://doi.org/10.1101/2023.12.08.570782  
  3. Wang Q. et al 2023. XBB.1.5 i-monovalent mRNA vaccine booster ivuselela amasosha omzimba aqinile ngokumelene nezinhlobonhlobo ezivelayo ze-SARS-CoV-2. Ukuphrinta kuqala i-bioRxiv. Kuthunyelwe Disemba 06, 2023. DOI: https://doi.org/10.1101/2023.11.26.568730  
  4. Isikhungo Sokulawulwa Kwesifo. Isibuyekezo ku-SARS-CoV-2 Okuhlukile kwe-JN.1 Kulandelwa yi-CDC. Itholakala ngo https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html   

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Umesh Prasad
Umesh Prasad
Intatheli yesayensi | Umhleli ongumsunguli, umagazini we-Scientific European

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