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I-COVID-19: Ukutheleleka okukhulu kwamaphaphu kuthinta inhliziyo “ngokushintsha kwe-macrophage yenhliziyo” 

Kuyaziwa ukuthi Covid-19 kwandisa ingozi isifo senhliziyo, unhlangothi, kanye Nende Covid kodwa obekungaziwa wukuthi umonakalo uyenzeka yini ngoba igciwane lithelela izicubu zenhliziyo ngokwalo, noma ngenxa ye-systemic ukuvuvukala okuqalwa ukusabela komzimba kugciwane. Ocwaningweni olusha, abacwaningi bathola ukuthi ukutheleleka kwe-SARS-CoV-2 kwenyuse isamba sama-macrophage enhliziyo futhi kwabenza basuka emsebenzini wabo ojwayelekile bavuvukala. Ama-macrophage enhliziyo avuvukalayo alimaza inhliziyo kanye nomzimba wonke. Abaphenyi baphinde bathola ukuthi ukuvimba impendulo yokuzivikela komzimba nge-antibody engathathi hlangothi emodeli yezilwane kumise ukugeleza kwenhliziyo evuvukalayo. macrophages nomsebenzi wenhliziyo ogciniwe okhombisa ukuthi le ndlela inamandla okwelapha. 

Kuyaziwa ukuthi i-COVID-19 inyusa ubungozi bokuhlaselwa yinhliziyo, unhlangothi, kanye ne-Long COVID. Abantu abangaphezu kuka-50% abathola i-COVID-19 bathola ukuvuvukala noma ukulimala kwenhliziyo. Obekungaziwa ukuthi umonakalo wenzeka yini ngoba igciwane lithelela izicubu zenhliziyo ngokwalo, noma ngenxa yokuvuvukala kwesistimu okubangelwa ukusabela komzimba kugciwane. 

Ucwaningo olusha lusikhanyisela ngesixhumanisi phakathi kokulimala kabi kwamaphaphu ku-COVID-19 enzima kanye nokuvuvukala okungaholela ezinkingeni zenhliziyo nemithambo yegazi. Ucwaningo lugxile kumangqamuzana omzimba omzimba aziwa ngokuthi ama-macrophages enhliziyo, ngokuvamile enza indima ebalulekile ekugcineni izicubu ziphilile kodwa zibe zivuvukala ekuphenduleni ukulimala okufana nokuhlasela kwenhliziyo noma ukuhluleka kwenhliziyo.  

Abacwaningi bahlaziye izibonelo zezicubu zenhliziyo ezigulini ezingama-21 ezashona ngenxa ye-SARS-CoV-2-associated acute Respiratory Distress Syndrome (ARDS) futhi baziqhathanisa nezibonelo zeziguli ezingama-33 ezashona ngenxa yezizathu ezingezona i-COVID-19. Ukulandela okwenzeka kuma-macrophages ngemuva kokutheleleka, abacwaningi baphinde bathelela amagundane ngawo I-SARS-CoV-2.  

Kwatholakala ukuthi ukutheleleka kwe-SARS-CoV-2 kwenyusa inani eliphelele lama-macrophage enhliziyo kubantu kanye namagundane. Ukutheleleka kuphinde kwabangela ukuthi ama-macrophages enhliziyo asuke emsebenzini wawo ojwayelekile abe ukuvuvukala. Ama-macrophages avuvukalayo alimaza inhliziyo nawo wonke umzimba.    

Ucwaningo lwenziwe ngamagundane ukuze kuhlolwe ukuthi ingabe impendulo abayibonile yenzeka ngoba i-SARS-CoV-2 yayithelela inhliziyo ngokuqondile, noma ngenxa yokuthi ukutheleleka kwe-SARS-CoV-2 emaphashini kwakubi ngokwanele ukwenza ama-macrophages enhliziyo avuvukale kakhulu. Lolu cwaningo lulingise izimpawu zokuvuvukala kwamaphaphu, kodwa ngaphandle kokuba khona kwegciwane langempela. Kutholwe ukuthi noma lingekho igciwane, amagundane akhombisa izimpendulo zokuzivikela eziqine ngokwanele ukuthi zikhiqize ukushintsha kwenhliziyo okufanayo okwabonwa ezigulini ezabulawa yi-COVID-19 kanye namagundane atheleleke nge-SARS-CoV-2. . 

Igciwane le-SARS-CoV-2 lilimaza ngqo izicubu zamaphaphu. Ngemva kwe-a Covid ukutheleleka, ngaphezu kokulimala okuqondile kwegciwane, amasosha omzimba angalimaza ezinye izitho ngokubangela ukuvuvukala okunamandla kuwo wonke umzimba.  

Kuyathakazelisa ukuthi kuphinde kwatholakala ukuthi ukuvimbela impendulo yokuzivikela komzimba nge-antibody engathathi hlangothi kumagundane kumise ukugeleza kwama-macrophages enhliziyo evuthayo kanye nomsebenzi wenhliziyo ogcinwe. Lokhu kubonisa ukuthi le ndlela (okungukuthi. ukucindezela ukuvuvukala kungase kunciphise izinkinga) inamandla okwelapha uma itholakala iphephile futhi isebenza ngempumelelo ekuhlolweni komtholampilo.  

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References:  

  1. I-NIH. Ukukhishwa kwezindaba - Ukutheleleka okukhulu kwamaphaphu ngesikhathi se-COVID-19 kungadala ukulimala kwenhliziyo. Kuthunyelwe ngomhla ka-20 Mashi 2024. Itholakala e- https://www.nih.gov/news-events/news-releases/severe-lung-infection-during-covid-19-can-cause-damage-heart 
  1. Grune J., et al 2024. I-Virus-Induced Acute Respiratory Distress Syndrome Idala I-Cardiomyopathy Ngokukhipha Izimpendulo Ezivuvukalayo Enhliziyweni. Ukujikeleza. 2024;0. Ishicilelwe ekuqaleni zingama-20 kuNdasa 2024. DOI: https://doi.org/10.1161/CIRCULATIONAHA.123.066433  

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