Isibulala-magciwane se-cephalosporin sesizukulwane sesihlanu esibanzi, i-Zevtera (Ceftobiprole medocaril sodium Inj.) sigunyazwe yi-FDA1 ukuze zelashwe izifo ezintathu okungukuthi. Izifo ze-Staphylococcus aureus bloodstream (bacteremia) (SAB), kuhlanganise nalabo abane-endocarditis ye-infective kwesokudla; izifo zesikhumba eziyingozi zebhaktheriya kanye nesakhiwo sesikhumba (ABSSSI);...
I-Rezdiffra (resmetirom) igunyazwe yi-FDA yase-USA ukuze zelashwe abantu abadala abane-noncirrhotic non-alcoholic steatohepatitis (NASH) enezibazi zesibindi ezimaphakathi kuya kweziphambili (fibrosis), ukuthi zisetshenziswe kanye nokudla nokuzivocavoca. Kuze kube manje, iziguli ezine...
I-World Health Organization (WHO) ishicilele incwadi entsha, ephelele yokuxilonga yezinkinga zengqondo, zokuziphatha, kanye ne-neurodevelopmental disorders. Lokhu kuzosiza abaqeqeshiwe bezempilo yengqondo nabanye ochwepheshe bezempilo ukuthi bahlonze futhi bahlonze ukuphazamiseka kwengqondo, ukuziphatha kanye ne-neurodevelopmental kuzilungiselelo zomtholampilo...
NgoFebhuwari 2024, amazwe amahlanu esifundeni se-WHO saseYurophu (i-Austria, Denmark, Germany, Sweden kanye ne-Netherlands) abike ukwanda okungajwayelekile kwamacala e-psittacosis ngo-2023 nasekuqaleni kuka-2024, okumakwe ikakhulukazi kusukela ngoNovemba-Disemba 2023. Ukufa kwabahlanu. ..
I-Iloprost, i-analogue yokwenziwa ye-prostacyclin esetshenziswa njenge-vasodilator ukwelapha i-pulmonary arterial hypertension (PAH), igunyazwe yi-US Food and Drug Administration ukuze kwelashwe isithwathwa esinamandla. Lona umuthi wokuqala ogunyazwe e-USA wokwelapha...
Ukumelana nemithi elwa namagciwane ikakhulukazi ngamagciwane angenayo i-Gram-negative cishe sekudale inkinga efana nesimo. Imithi elwa namagciwane inoveli iZosurabalpin (RG6006) ibonisa izithembiso. Kutholwe ukuthi kusebenza ngempumelelo ngokumelene nebhaktheriya elingazweli emuthini, i-Gram-negative CRAB ezifundweni zangaphambi komtholampilo. Ukumelana ne-Antimicrobial (AMR), eqhutshwa ikakhulukazi ...
I-Mindfulness meditation (MM) ingaba indlela esebenzayo yokudambisa yokuhlinzwa kokufakelwa kwamazinyo okwenziwa ngaphansi kwe-anesthesia yendawo.
Ukuhlinzwa kokufakelwa kwamazinyo kuthatha amahora angu-1-2. Iziguli cishe zihlala zizwa zikhathazekile phakathi nenqubo okuholela ekucindezelekeni kwengqondo nokwanda kozwelo...
Umuthi wokugoma omusha, i-R21/Matrix-M unconywe yi-WHO ukuze kuvinjelwe umalaleveva ezinganeni. Ngasekuqaleni kuka-2021, i-WHO yancoma umuthi wokugomela umalaleveva i-RTS,S/AS01 ukuze kuvinjelwe umalaleveva ezinganeni. Lona bekuwumgomo wokuqala wokugomela umalaleveva...
Umklomelo kaNobel wePhysiology noma Medicine 2023 walo nyaka uklonyeliswe ngokuhlanganyela kuKatalin Karikó kanye noDrew Weissman "ngokutholwa kwabo maqondana nokuguqulwa kwesisekelo se-nucleoside okwenze kwasungulwa imigomo esebenzayo ye-mRNA yokulwa ne-COVID-19". Bobabili uKatalin Karikó kanye...
I-Amoeba edla ubuchopho (i-Naegleria fowleri) inesibopho sokutheleleka kobuchopho okwaziwa nge-primary amoebic meningoencephalitis (PAM). Izinga lokutheleleka liphansi kakhulu kodwa liyabulala kakhulu. Igciwane lithintwa ngokuthatha amanzi angcoliswe i-N. fowleri ngamakhala. Ama-antibiotics...
Abacwaningi bathole ukuthi inkumbulo enkawuni esekhulile iba ngcono kulandela ukuphathwa okukodwa komthamo ophansi weprotheyini ye-Klotho. Kungokokuqala ukuthi ukubuyisela amazinga e-klotho kuboniswe ukuthuthukisa ukuqonda ku-primate okungeyena umuntu. Lokhu kuvula i...
Ocwaningweni lwakamuva lwe-in-vivo lwe-Zebrafish, abacwaningi baye bathola ngempumelelo ukukhiqizwa kabusha kwediski kudiski eyonakele ngokwenza kusebenze i-endogenous Ccn2a-FGFR1-SHH esiginali ye-cascade. Lokhu kuphakamisa ukuthi iphrotheni ye-Ccn2a ingasetshenziswa ekukhuthazeni ukuvuselelwa kwe-IVD yokwelashwa komgogodla. Emuva...
Besebenzisa ama-enzyme afanele, abacwaningi bakhiphe ama-antigen eqembu legazi le-ABO kumnikeli wezinso namaphaphu ex-vivo, ukuze banqobe ukungafani kweqembu legazi le-ABO. Le ndlela ingaxazulula ukushoda kwezitho zomzimba ngokwenza ngcono ukutholakala kwezitho zabanikeli ukuze zifakwe kabusha futhi yenze ...
Ngomhla ziyisi-08 kuNcwaba wezi-2022, ithimba lochwepheshe be-WHO lafika ekuvumelaneni nge-nomenclature yezinhlobo noma izinhlobo ezintsha ze-monkeypox virus (MPXV). Ngakho-ke, isigaba sangaphambili saseCongo Basin (Central African) sizokwaziwa ngokuthi iClade one(I) kanye...
Ama-henipavirus amabili, i-Hendra virus (HeV) kanye ne-Nipah virus (NiV) kakade aziwa ngokudala isifo esibulalayo kubantu. Manje, sekuhlonzwe i-henipavirus yenoveli ezigulini ezine-febrile eMpumalanga China. Lolu uhlobo oluhlukile lwe-phylogenetically lwe-henipavirus ...
Igciwane lemonkeypox (MPXV) lihlobene eduze nengxibongo, igciwane elibulala kakhulu emlandweni elibangela ukucekelwa phansi okungenakuqhathaniswa kwabantu emakhulwini eminyaka adlule okubalele ukufa kwabantu abaningi kunanoma yisiphi esinye isifo esithathelwanayo, ngisho nesifo kanye nesifo sohudo. Nge...
Ukuthuthukiswa ngempumelelo kwemithi yokugomela i-mRNA, i-BNT162b2 (ye-Pfizer/BioNTech) kanye ne-mRNA-1273 (ye-Moderna) ngokumelene ne-coronavirus yenoveli i-SARS CoV-2 kanye nendima ebalulekile edlalwe yile migomo muva nje ekugomeni abantu abaningi ngokumelene nobhubhane lwe-COVID-19 emazweni amaningana. usungule...
Ubuchwepheshe be-RNA bukhombise ukubaluleka kwabo muva nje ekuthuthukisweni kwemithi yokugomela i-mRNA i-BNT162b2 (ye-Pfizer/BioNTech) kanye ne-mRNA-1273 (ye-Moderna) ngokumelene ne-COVID-19. Ngokusekelwe ekwehliseni isithunzi i-RNA yokufakwa kwekhodi kumodeli yezilwane, ososayensi baseFrance babike isu elinamandla kanye nobufakazi...
Odokotela nososayensi baseNyuvesi yaseMaryland School of Medicine bafake ngempumelelo inhliziyo yengulube eyenziwe ngofuzo (GEP) esigulini esikhulile esinesifo senhliziyo esifika esigabeni sokugcina. Lokhu kuhlinzwa bekuwukuphela kwenketho yesiguli esele yokusinda ngemuva kokuthi...
Ama-nanostructures azihlanganisele akhiwe kusetshenziswa ama-polymers e-supramolecular aqukethe ama-peptide amphiphiles (PAs) aqukethe ukulandelana okusebenzayo kwe-bio abonise imiphumela emihle kumodeli yegundane ye-SCI futhi anesithembiso esikhulu, kubantu, sokwelashwa okuphumelelayo kwalesi simo esiwohlozayo esithinta kakhulu izinga lempilo. ...
Ukuthuthukiswa kwamagciwane amaningi ongamelani nezidakamizwa (MDR) eminyakeni engamashumi amahlanu edlule kuye kwaholela ekwandeni kocwaningo ekufuneni umuntu ozongenela isidakamizwa ukuze kubhekwane nalolu daba lwe-AMR. Isibulala-magciwane esakhiwe ngokugcwele esibanzi, i-Iboxamycin, sinikeza ithemba lokwelapha kokubili amagciwane e-Gram-positive kanye ne-Gram-negative...
Ukuthuthukisa umuthi wokugomela umalaleveva kube phakathi kwezinselelo ezinkulu ngaphambi kwesayensi. I-MosquirixTM, umuthi wokugomela umalaleveva usanda kugunyazwa yi-WHO. Nakuba ukusebenza kwalo mgomo kucishe kube ngama-37%, nokho lesi yisinyathelo esihle esiya phambili njengoba lesi...
I-Donepezil iyi-acetylcholinesterase inhibitor1. I-Acetylcholinesterase idiliza i-neurotransmitter acetylcholine2, ngaleyo ndlela yehlise ukusayina kwe-acetylcholine ebuchosheni. I-Acetylcholine (ACh) ithuthukisa umbhalo wekhodi wezinkumbulo ezintsha futhi ngenxa yalokho ithuthukisa ukufunda3. I-Donepezil ithuthukisa ukusebenza komqondo ekukhubazekeni kwengqondo okuncane (MCI)...
I-Selegiline iyi-monoamine oxidase (MAO) B inhibitor1 engenakuhlehla. Ama-neurotransmitters e-Monoamine, njenge-serotonin, i-dopamine ne-norepinephrine, aphuma kuma-amino acid2. I-enzyme i-monoamine oxidase A (MAO A) ngokuyinhloko i-oxidise (iphuka) i-serotonin ne-norepinephrine ebuchosheni, ...
Izifo ze-Fibrotic zaziwa ukuthi zithinta izitho ezimbalwa ezibalulekile emzimbeni futhi ziyimbangela enkulu yokufa nokugula. Kube khona impumelelo encane ekwelashweni kwalezi zifo kuze kube manje. I-ILB®, Isisindo Somzimba Esiphansi...
