I-Iloprost, i-analogue yokwenziwa ye-prostacyclin esetshenziswa njenge-vasodilator ukuze phatha I-pulmonary arterial hypertension (PAH), igunyazwe yi-US Ukudla kanye neDrug Administration yokwelapha isithwathwa esinzima. Lokhu kuqala ukugunyazwa imithi e-USA ukwelapha isithwathwa esinzima kubantu abadala ukunciphisa ingozi yokunqunywa isitho.
I-Frostbite yisimo esibucayi esidinga ngokushesha zezokwelapha ukunaka. Kubangelwa ukuchayeka emazingeni okushisa aqandayo isikhathi eside ngokwanele ukuvumela amakristalu eqhwa ukuthi akhe ezicutshini. Abantu abasebenza ngaphandle ezindaweni ezibandayo njengabonogada, abasebenzi basezimbonini, abaqwala izintaba noma abaqwala izintaba njalo njalo bavame ukuthinteka yiqhwa. Ukunqunywa kweminwe nezinzwane ngenxa yeqhwa kuvamile ezindaweni ezinjalo naphezu kwentuthuko zezempilo izinsiza zokunakekela.
I-Iloprost iyi-analog yokwenziwa ye-prostacyclin. Ihlehlisa i-vasoconstriction futhi ivimbele ukusebenza kweplatelet, isebenza njenge-vasodilator, ivula imithambo yegazi futhi ivimbele ukujiya kwegazi. Yaqala ukugunyazwa ngo-2004 ukwelashwa kwe-pulmonary arterial hypertension (PAH).
I-Iloprost kanye ne-thrombolytics inenzuzo ekwelapheni i-frostbite. ECanada, iziguli enesithwathwa esinzima esihilela ukugodola kwesikhumba kanye nezicubu ezingaphansi kanye nokumiswa kokugeleza kwegazi kuye kwaphathwa ngempumelelo nge-iloprost. Umuthi omdala manje usuvunyiwe yi-US Food and Drug Administration (FDA) ukwelapha isithwathwa esinzima.
The FDA inikeze imvume ku-Eicos Sciences Inc. ukuthi yenze iloprost yokwelapha isithwathwa esinamandla ngegama lomkhiqizo elithi "Aurlumyn".
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References:
- FDA Igunyaza Umuthi Wokuqala Wokwelapha I-Frostbite Enzima. Kuthunyelwe ngomhla ka-14 February 2024. Itholakala e- https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-treat-severe-frostbite/
- Regli, IB, Oberhammer, R., Zafren, K. et al. Ukwelashwa kwe-Frostbite: ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta. I-Scand J Trauma Resusc Emerg Med 31, 96 (2023). https://doi.org/10.1186/s13049-023-01160-3
- U-Poole A. no-Gauthier J. 2016. Ukwelashwa kwesithwathwa esinamandla nge-iloprost enyakatho yeCanada. I-CMAJ Disemba 06, 2016 188 (17-18) 1255-1258; I-DOI: https://doi.org/10.1503/cmaj.151252
- UGruber, E., Oberhammer, R., Brugger, H. et al. Ukungcwatshwa kwe-avalanche ebucayi isikhathi eside cishe amahora angama-23 nge-hypothermia eqinile kanye nesithwathwa esinamandla esilulama kahle: umbiko wecala. I-Scand J Trauma Resusc Emerg Med 32, 11 (2024). https://doi.org/10.1186/s13049-024-01184-3
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