Imiphumela evela esivivinyweni se-phase2 isekela umbono wokuthi ukuphathwa okungaphansi kwe-IFN- β yokwelashwa kwe-COVID-19 kuthuthukisa isivinini sokululama futhi kunciphisa nokufa..
Isimo esingajwayelekile esethulwe wubhubhane lwe-COVID-19 sigunyaze ukuthi kubhekwe izindlela ezahlukahlukene zokwelashwa kwamacala abucayi e-COVID-19. Imishanguzo eminingi emisha iyazanywa futhi izidakamizwa ezikhona ziyasetshenziswa kabusha. Corticosteroids kakade kutholakale ukuthi ziwusizo. Ukwelashwa kwe-Interferon sekuvele kusetshenziselwa izifo ezibangelwa amagciwane njenge-hepatitis. Ingabe i-IFN ingasetshenziswa ngokumelene ne-SARS CoV-2 ku-COVID-19?
Ezivivinyweni zangaphambi komtholampilo ngaphambili, i-IFN ibonakale iphumelela ngokumelene ne-SARS CoV kanye AMADODA amagciwane. NgoJulayi 2020, ukuphathwa kwe-Interferon-β ngokusebenzisa umzila we-nebulisation (okungukuthi. 1,2.
Manje, umbiko wakamuva osuselwe kudatha yesigaba sesi-2 sokuhlolwa komtholampilo okwenziwa ezigulini eziyi-112 ezine-COVID-19 ezilaliswe esibhedlela e-Pitié-Salpêtrière eParis, eFrance uphakamisa ukuthi ukuphathwa kwe-IFN- β ngomzila ongaphansi kwesikhumba kuthuthukisa izinga lokululama futhi kunciphisa nokufa ku-COVID-19. amacala 3.
Ama-Interferon (IFN) angamaprotheni akhiqizwe amaseli abamba iqhaza ekuphenduleni izifo ezibangelwa amagciwane ukuze abonise amanye amaseli ukuba khona kwegciwane. Ukusabela okweqile kokuvuvukala kwezinye zeziguli ze-COVID-19 kutholakala kuhlotshaniswa nokusabela okungalungile kwe-IFN-1 kanye nokuvinjwa. I-IFN-β imfihlo. Isetshenziswa ku China ukwelapha i-viral pneumonia ngenxa ye-SARS CoV nokho ukusetshenziswa kwayo akujwayelekile 4.
Ukuhlolwa komtholampilo kwesigaba 3 sokusetshenziswa kwe-Interferons (IFN) ekwelapheni iziguli ezinzima ze-COVID-19 kuyaqhubeka okwamanje. Ukugunyazwa kuzoncika ekutheni imiphumela yokugcina ingaphakathi kwebanga elamukelekayo elishiwo abalawuli.
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Imithombo:
- I-NHS 2020. Izindaba- Umuthi ohogelwe uvimbela iziguli ze-COVID-19 ukuba zibe zimbi kakhulu ovivinyweni lwaseSouthampton. Kuthunyelwe ngomhla ka-20 Julayi 2020. Itholakala ku-inthanethi kokuthi https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx Ifinyelelwe ngomhla ka-12 February 2021.
- I-Monk PD., Marsden RJ., Tear VJ., et al., 2020. Ukuphepha nokusebenza ngempumelelo kwe-interferon beta-1a ephefumulelwe nebulised (SNG001) yokwelashwa kokutheleleka kwe-SARS-CoV-2: okungahleliwe, okungaboni kabili, i-placebo- kulawulwa, isigaba sesi-2 sokulinga. I-Lancet Respiratory Medicine, Itholakala ku-inthanethi ngomhla ka-12 Novemba 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7
- Dorgham K., Neumann AU., et al 2021. Kucatshangelwa ukwelashwa kwe-Interferon-β komuntu siqu kwe-COVID-19. Ama-Agent Antimicrobial Chemotherapy. Kuthunyelwe ku-inthanethi ngomhla ka-8 February 2021. DOI: https://doi.org/10.1128/AAC.00065-21
- UMary A., Hénaut L., Macq PY., et al 2020. Isizathu Sokwelashwa kwe-COVID-19 nge-Nebulised Interferon-β-1b–Literature Review kanye Nokuhlangenwe nakho Kwakho Komuntu Kwasekuqaleni. I-Frontiers in Pharmacology., 30 Novemba 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.
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